THE WBLC/WHIB7 TRANSCRIPTION FACTOR CONTROLS INTRINSIC RESISTANCE TO TRANSLATION-TARGETING ANTIBIOTICS BY ALTERING RIBOSOME COMPOSITION

The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition

ABSTRACT Bacteria that encounter antibiotics can efficiently change their physiology to develop resistance.This intrinsic antibiotic resistance is mediated by multiple pathways, including a regulatory system(s) that activates specific genes.In some Streptomyces and Mycobacterium spp., the WblC/WhiB7 transcription factor is required for intrinsic re

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Exploring the mechanism of Semen Cuscutae processed with salt solution in improving kidney deficiency miscarriage based on serum pharmacochemistry and network pharmacology

Semen Cuscutae (S) is an effective traditional Chinese medicine (TCM) in clinical practice for tonifying the kidney and calming the fetus.The effects of S on benefiting the kidney, fixing essence and calming the fetus were enhanced after salt processed.However, its bioactive substance and relevant mechanism have not been clearly yet.This study aims

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